Deltasone 20 mg – Drug information
One of the most frequently prescribed anti-inflammatory drugs is Deltasone. Deltasone is available in the form of 20 mg tablets.
The primary active component of the drug is prednisone which is a synthetic analog of the hormone hydrocortisone and has a similar effect.
The primary functions of the drug are: anti-inflammatory, immunosuppressive, antiallergic, anti-shock.
Deltasone affects virtually all stages of the inflammatory process, suppresses the synthesis of inflammatory mediators and prevents the migration of cells of the immune system.
Deltasone retards sodium in the body, but it stimulates the excretion of potassium, reduces the mineralization of bone tissue and slows the absorption of calcium from the gastrointestinal tract.
Deltasone also has an immunosuppressive effect. It interferes with lymphocytes and their migration, reduces the intensity of antibody formation, blocks the release of interferons.
Antiallergic effect is manifested by a decrease in the secretion of inflammatory mediators, inhibition of release from mast cells of histamine, suppression of the activity of lymphocytes in the blood. Deltasone reduces the sensitivity of receptors in various tissues to mediators of inflammation.
The drug is most often used to relieve the symptoms of inflammatory processes of medium and high severity. These processes can be localized in the following parts of the body: musculoskeletal system, lungs, gastrointestinal tract, muscles, nervous system, leather, eyes.
The drug is also used in such a dangerous complication as cerebral edema. This condition can arise as a result of injuries, infectious and inflammatory processes, and surgical intervention.
The drug is also used for severe bronchial asthma, systemic connective tissue diseases (systemic lupus erythematosus, scleroderma, rheumatoid arthritis).
Deltasone in tablets has one dosage options – 20 mg.
The standard daily dose in tablets for most diseases is 20-30 mg. The maintenance dose is 5-10 mg. In severe cases, a dose exceeding the standard dosage may be prescribed up to 100 mg/day.
If the dose is small, then all the tablets are best taken in the morning. If the dose is significant, then it can be divided into 2-4 admission, with most of the daily dose taken in the morning.
The minus of the medication is its inherent effect of withdrawal syndrome. You shouldn’t abruptly stop a long course of treatment, since in this case, there may be a withdrawal syndrome, as well as an aggravation of the symptoms of the disease for which therapy was prescribed. It is necessary to reduce the dose gradually, until the body is accustomed to low doses of hormones that come with the medication, and will not switch to their own.
The medication cannot be used in all cases.
With caution appoint the drug for: thyrotoxicosis; hypertension; renal and hepatic insufficiency; diabetes mellitus; Cushing’s syndrome; obesity of 3-4 degrees; systemic osteoporosis; psychoses, including, in the anamnesis; poliomyelitis; glaucoma; gastritis, peptic ulcer of the stomach and duodenum, nonspecific ulcerative colitis with perforation threat, esophagitis, peptic ulcer.
The medicine affects various biochemical and physiological processes in the body. And this means that it affects various body systems resulting in the occurrence of side effects.
On the part of the endocrine system, the following types of side effects are possible: a decrease in glucose tolerance, steroid diabetes mellitus, oppression of adrenal function, Cushing’s syndrome, delay in sexual development in children.
From the gastrointestinal tract the following negative phenomena are possible: nausea, vomiting, a decrease in appetite, ulcer of the stomach and duodenum, dyspepsia, hiccups.
Side effects from the cardiovascular system: arrhythmias, bradycardia, changes in ECG parameters, arterial hypertension.
From the side of the nervous system the following disturbances are possible: euphoria, disorientation, hallucinations, affective insanity, depression, paranoia, increased intracranial pressure, nervousness, dizziness, headache, convulsions.
In addition, against the background of taking medication, the following pathologies are associated with metabolic disorders: acceleration of the excretion of potassium from the body, weight gain, the retention of fluid and sodium in the body, decrease in body weight.
Many, for sure, are interested in the question of whether it is possible to use the drug during pregnancy. It is not recommended. The thing is that the Deltasone, which is in its composition, penetrates the fetus, and, as shown, studies in animals, is capable of producing a teratogenic effect, that is, negatively affecting the development of the fetus.